The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Sep. 21, 2011
Hing C. Wong, Weston, FL (US);
Peter Rhode, Miami, FL (US);
Bai Liu, Cooper City, FL (US);
Xiaoyun Zhu, Miami, FL (US);
Kai-ping Han, Miramar, FL (US);
Hing C. Wong, Weston, FL (US);
Peter Rhode, Miami, FL (US);
Bai Liu, Cooper City, FL (US);
Xiaoyun Zhu, Miami, FL (US);
Kai-ping Han, Miramar, FL (US);
Altor BioScience Corporation, Miramar, FL (US);
Abstract
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.