The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Sep. 22, 2009
Zonghai LI, Shanghai, CN;
Huamao Wang, Shanghai, CN;
Hua Jiang, Shanghai, CN;
Bizhi Shi, Shanghai, CN;
Jianren Gu, Shanghai, CN;
Shengli Yang, Shanghai, CN;
Zonghai Li, Shanghai, CN;
Huamao Wang, Shanghai, CN;
Hua Jiang, Shanghai, CN;
Bizhi Shi, Shanghai, CN;
Jianren Gu, Shanghai, CN;
Shengli Yang, Shanghai, CN;
Shanghai Cancer Institute, Shanghai, CN;
Abstract
The invention provides specific binding proteins and the uses thereof. Particularly, the present invention provides a monoclonal antibody which can effectively bind to epidermal growth factor receptor variant type III (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but not bind to EGFR normally-expressed in cells. Furthermore, the present invention said antibody has obvious therapeutic effect on a tumor cell line expressing the EGFRvIII. The invention also provides a method for preparing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody.