The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Sep. 06, 2012
Christian Kemmer, Riehen, CH;
David Fluri, Zürich, CH;
Ulrich Witschi, Liebefeld, CH;
Wilfried Weber, Freiburg im Breisgau, DE;
Martin Fussenegger, Mägenwil, CH;
Christian Kemmer, Riehen, CH;
David Fluri, Zürich, CH;
Ulrich Witschi, Liebefeld, CH;
Wilfried Weber, Freiburg im Breisgau, DE;
Martin Fussenegger, Mägenwil, CH;
ETH Zurich, Zurich, CH;
Swissgenetics, Zollikofen, CH;
Abstract
The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.