The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Apr. 28, 2010
David Kenneth Dean, Harlow, GB;
Jorge Munoz-muriedas, Stevanage, GB;
Mairi Sime, Harlow, GB;
Jon Graham Anthony Steadman, Harlow, GB;
Rachel Elizabeth Anne Thewlis, Harlow, GB;
Giancarlo Trani, Harlow, GB;
Daryl Simon Walter, Harlow, GB;
David Kenneth Dean, Harlow, GB;
Jorge Munoz-Muriedas, Stevanage, GB;
Mairi Sime, Harlow, GB;
Jon Graham Anthony Steadman, Harlow, GB;
Rachel Elizabeth Anne Thewlis, Harlow, GB;
Giancarlo Trani, Harlow, GB;
Daryl Simon Walter, Harlow, GB;
Glaxo Group Limited, Greenford, Middlesex, GB;
Abstract
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, Calkyl, Ccycloalkyl, Calkoxy, Calkoxy Calkyl, Cfluoroalkyl, halogen, NRR, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R, R, R, R, R, Rand Rare as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.