The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Dec. 15, 2011
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
David L. Lewis, Madison, WI (US);
Jon A. Wolff, Madison, WI (US);
Andrei V. Blokhin, Fitchburg, WI (US);
Jonathan D. Benson, Stoughton, WI (US);
Jeffrey C. Carlson, Madison, WI (US);
Philipp Hadwiger, Kulmbach, DE;
Eric A. Kitas, Aesch BL, CH;
Torsten Hoffmann, Weil am Rhein, DE;
Kerstin Jahn-hofmann, Neu-Isenburg, DE;
Peter Mohr, Basel, CH;
Hans Martin Mueller, Munich, DE;
Guenther Ott, Bayreuth, DE;
Ingo Roehl, Memmelsdorf, DE;
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
David L. Lewis, Madison, WI (US);
Jon A. Wolff, Madison, WI (US);
Andrei V. Blokhin, Fitchburg, WI (US);
Jonathan D. Benson, Stoughton, WI (US);
Jeffrey C. Carlson, Madison, WI (US);
Philipp Hadwiger, Kulmbach, DE;
Eric A. Kitas, Aesch BL, CH;
Torsten Hoffmann, Weil am Rhein, DE;
Kerstin Jahn-Hofmann, Neu-Isenburg, DE;
Peter Mohr, Basel, CH;
Hans Martin Mueller, Munich, DE;
Guenther Ott, Bayreuth, DE;
Ingo Roehl, Memmelsdorf, DE;
Arrowhead Madison Inc., Madison, WI (US);
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.