The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Aug. 13, 2009
Yutaka Kanda, Tokyo, JP;
Hiroshi Sato, Tokyo, JP;
Tsuyoshi Yamada, Tokyo, JP;
Akifumi Kato, Tokyo, JP;
Mitsuo Satoh, Tokyo, JP;
Yutaka Kanda, Tokyo, JP;
Hiroshi Sato, Tokyo, JP;
Tsuyoshi Yamada, Tokyo, JP;
Akifumi Kato, Tokyo, JP;
Mitsuo Satoh, Tokyo, JP;
Kyowa Hakko Kirin Co., Ltd, Tokyo, JP;
Abstract
A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as 'RAGE') than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.