The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Nov. 08, 2011
Piet Herdewijn, Wezemaal, BE;
Christophe Pannecouque, Heverlee, BE;
Tongfei Wu, Leuven, BE;
Erik DE Clercq, Bierbeek, BE;
Piet Herdewijn, Wezemaal, BE;
Christophe Pannecouque, Heverlee, BE;
Tongfei Wu, Leuven, BE;
Erik De Clercq, Bierbeek, BE;
K.U.Leuven Research & Development, Leuven, BE;
Abstract
The invention is directed to phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base, as well as pharmaceutical compositions thereof. These compounds, which can be described by general formula (II), are useful for the treatment of retroviral infection, e.g., HIV (Human Immunodeficiency Virus) infection in a mammal. The invention also features synthetic intermediates for the preparation of phosphonate nucleosides.