The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Aug. 29, 2006
C. Frank Bennett, Carlsbad, CA (US);
Nicholas M. Dean, Olivenhain, CA (US);
Ryszard Kole, Chapel Hill, NC (US);
Casey C. Kopczynski, Chapel Hill, NC (US);
C. Frank Bennett, Carlsbad, CA (US);
Nicholas M. Dean, Olivenhain, CA (US);
Ryszard Kole, Chapel Hill, NC (US);
Casey C. Kopczynski, Chapel Hill, NC (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Sarepta Therapeutics, Cambridge, MA (US);
Abstract
Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.