The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Oct. 15, 2008
Joachim Grötzinger, Altwittenbek, DE;
Jürgen Scheller, Kiel, DE;
Stephanie Tenhumberg, Schwetzingen, DE;
Stefan Rose-john, Schellhorn, DE;
Georg H. Wätzig, Kiel, DE;
Joachim Grötzinger, Altwittenbek, DE;
Jürgen Scheller, Kiel, DE;
Stephanie Tenhumberg, Schwetzingen, DE;
Stefan Rose-John, Schellhorn, DE;
Georg H. Wätzig, Kiel, DE;
Conaris Research Institute AG, Kiel, DE;
Abstract
Described are soluble gp130 polypeptide monomers and dimers, wherein, in a preferred embodiment, at least one of the three amino acid residues ThrGlnor Asnof the N-terminal Ig-like domain of gp130 is mutated to Tyr, Pheor Leu, respectively. These mutations, alone or in combination, specifically enhance binding of gp130 to its ligand complex of interleukin-6 and soluble interleukin-6 receptor, thus increasing the biological activity of the gp130 muteins. In a particularly preferred embodiment, all three mutations are combined in the triple mutein Thr102Tyr/Gln113Phe/Asn114Leu (T102Y/Q113F/N114L). Moreover, a pharmaceutical composition containing said monomers or dimers and various medical uses are described.