The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Jan. 17, 2012
Rebecca Pogue-caley, Durham, NC (US);
Tamara Monesmith, Durham, NC (US);
Irina Tcherepanova, Rougemont, NC (US);
Lois Dinterman, Kearneysville, WV (US);
Rebecca Pogue-Caley, Durham, NC (US);
Tamara Monesmith, Durham, NC (US);
Irina Tcherepanova, Rougemont, NC (US);
Lois Dinterman, Kearneysville, WV (US);
Argos Therapeutics, Inc., Durham, NC (US);
Abstract
Methods are provided for the production of dendritic cells from monocytes that have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6 to 96 hours from the time they are isolated from a subject. After the incubation period, the monocytes can then be induced to differentiate into dendritic cells. Mature dendritic cells made by the methods of the invention have increased levels of one or more of CD80, CD83, CD86, MHC class I molecules, or MHC class II molecules as compared to mature dendritic cells prepared from monocytes that have not been held at 1° C.-34° C. for at least 6 hours from the time they were isolated from a subject. Dendritic cells made by the methods of the invention are useful for the preparation of vaccines and for the stimulation of T cells.