The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2013
Filed:
Sep. 21, 2011
David Paul Weiner, Del Mar, CA (US);
Jennifer Ann Chaplin, San Diego, CA (US);
Dan E. Robertson, Belmont, MA (US);
Darcy Madden, La Mesa, CA (US);
Mark Madden, La Mesa, CA (US);
David Paul Weiner, Del Mar, CA (US);
Jennifer Ann Chaplin, San Diego, CA (US);
Dan E. Robertson, Belmont, MA (US);
Verenium Corporation, San Diego, CA (US);
Abstract
The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.