The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Aug. 22, 2011
Applicants:
Peter Madrid, San Francisco, CA (US);
Bryan Glaser, San Francisco, CA (US);
Jeremiah Malerich, San Francisco, CA (US);
Inventors:
Peter Madrid, San Francisco, CA (US);
Bryan Glaser, San Francisco, CA (US);
Jeremiah Malerich, San Francisco, CA (US);
Assignee:
SRI International, Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/203 (2006.01); C07D 311/50 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07H 15/203 (2013.01); C07D 405/12 (2013.01); C07D 311/50 (2013.01);
Abstract
An aminocoumarin conjugated to a fluorescent label through a secondary amine, is operative as a fluorescent polarization probe of the DNA gyrase B or topoisomerase IV E subunit. The probe is used for detecting topoisomerase inhibitor binding by fluorescence polarization, particularly in a high-through put topoisomerase inhibitor assay.