The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Jun. 04, 2012
Toru Hosoda, Chestnut Hill, MA (US);
Piero Anversa, Boston, MA (US);
Annarosa Leri, Boston, MA (US);
Jan Kajstura, Brookline, MA (US);
Toru Hosoda, Chestnut Hill, MA (US);
Piero Anversa, Boston, MA (US);
Annarosa Leri, Boston, MA (US);
Jan Kajstura, Brookline, MA (US);
New York Medical College, Valhalla, NY (US);
Abstract
The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.