The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Jul. 11, 2005
Katrin Eppelmann, Kalamazoo, MI (US);
Petrus M. M. Nossin, Nederweert, NL;
Leon J. R. M. Raeven, Sittard, NL;
Susanne M. Kremer, Linnich-Gereonsweiler, DE;
Marcel G. Wubbolts, Sittard, NL;
Katrin Eppelmann, Kalamazoo, MI (US);
Petrus M. M. Nossin, Nederweert, NL;
Leon J. R. M. Raeven, Sittard, NL;
Susanne M. Kremer, Linnich-Gereonsweiler, DE;
Marcel G. Wubbolts, Sittard, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.