The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Feb. 05, 2013
Historx, Inc., New Haven, CT (US);
Mark Gustavson, Niantic, CT (US);
Jennifer Giltnane, Nashville, TN (US);
Marisa P. Dolled-Filhart, New Haven, CT (US);
Robert L. Camp, San Francisco, CA (US);
David L. Rimm, Branford, CT (US);
HistoRx, Inc., New Haven, CT (US);
Yale University, New Haven, CT (US);
Abstract
The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.