The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2013
Filed:
Jun. 27, 2012
Katherine E. Lewis, Lake Forest Park, WA (US);
Scott R. Presnell, Tacoma, WA (US);
Steven D. Levin, Seattle, WA (US);
Robert Mabry, Hanover, NH (US);
Stephen R. Jaspers, Brewster, NY (US);
Monica J. Huber, Bothell, WA (US);
Katherine E. Lewis, Lake Forest Park, WA (US);
Scott R. Presnell, Tacoma, WA (US);
Steven D. Levin, Seattle, WA (US);
Robert Mabry, Hanover, NH (US);
Stephen R. Jaspers, Brewster, NY (US);
Monica J. Huber, Bothell, WA (US);
ZymoGenetics, Inc., Seattle, WA (US);
Abstract
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.