The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2013
Filed:
Jan. 20, 2010
Applicants:
George A. Oyler, Baltimore, MD (US);
Charles B. Shoemaker, North Grafton, MA (US);
Chuehling Kuo, Framingham, MA (US);
Inventors:
George A. Oyler, Baltimore, MD (US);
Charles B. Shoemaker, North Grafton, MA (US);
Chuehling Kuo, Framingham, MA (US);
Assignee:
Trustees of Tufts College, Medford, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); C12Q 1/02 (2006.01); C12N 5/07 (2010.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to methods, systems, and kits for intoxicating cells, neuronal and non-neuronal cells, with a toxin or fragment thereof. This is done by subjecting toxin substrate and a lipid or polymeric carrier (e.g., DNA uptake facilitating agent) to one or more cells for use in cell based assays. In an aspect, the methods of the present invention allow for high throughput assays and, as such, for the evaluation of drug candidates.