The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2013
Filed:
Mar. 11, 2003
Laura Borsi, Genoa, IT;
Barbara Carnemolla, Genoa, IT;
Enrica Balza, Genoa, IT;
Patrizia Castellani, Genoa, IT;
Luciano Zardi, Genoa, IT;
Matthias Friebe, Berlin, DE;
Christoph-stephan Hilger, Berlin, DE;
Laura Borsi, Genoa, IT;
Barbara Carnemolla, Genoa, IT;
Enrica Balza, Genoa, IT;
Patrizia Castellani, Genoa, IT;
Luciano Zardi, Genoa, IT;
Matthias Friebe, Berlin, DE;
Christoph-Stephan Hilger, Berlin, DE;
Philogen S.p.A., Sienna, IT;
Bayer Schering Pharma AG, Berlin, DE;
Abstract
The present invention relates to selectively targeting tumoral vasculature in vivo using a human recombinant scFv, L19, to the angiogenesis marker ED-B domain of fibronectin. In preferred embodiments, a complete human IgG1 is employed having the variable regions of L19. In other preferred embodiments is employed a mini-immunoglobulin generated by fusing the scFv L19 to the constant CH4 domain of a secretory IgE isoform that naturally contains a cysteine in its COOH terminal and which forms a covalently linked dimer. Different in vivo behavior of the antibody formats is exploitable for different diagnostic and/or therapeutic purposes, depending on clinical needs and disease. The antibody molecules may be labelled as described.