The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2013
Filed:
Nov. 25, 2009
Applicants:
Steve Roffler, Taipei, TW;
Chia-hung Wu, Tainan, TW;
Wolfgang Schechinger, Dieburg, DE;
Kai-chuan Chen, Kaohsiung, TW;
Zeljko Prijovic, Belgrade, RS;
Inventors:
Steve Roffler, Taipei, TW;
Chia-Hung Wu, Tainan, TW;
Wolfgang Schechinger, Dieburg, DE;
Kai-Chuan Chen, Kaohsiung, TW;
Zeljko Prijovic, Belgrade, RS;
Assignee:
Academia Sinica, Taipei, TW;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C12N 9/24 (2006.01); A61K 38/47 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); A61K 47/48138 (2013.01); C12N 9/2402 (2013.01); Y10S 424/801 (2013.01); Y10S 424/809 (2013.01);
Abstract
A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system.