The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Dec. 18, 2009
Applicants:
Pavel Hradil, Hlusovice, CZ;
Lubomir Kvapil, Slatinice, CZ;
Martin Grepl, Hlusovice, CZ;
Jan Novotny, Olomouc, CZ;
Inventors:
Pavel Hradil, Hlusovice, CZ;
Lubomir Kvapil, Slatinice, CZ;
Martin Grepl, Hlusovice, CZ;
Jan Novotny, Olomouc, CZ;
Assignee:
Farmak, A.S., Olomouc, CZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 285/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, after acidification with hydrogen chloride, tizanidine hydrochloride is obtained in a high yield and purity.