The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Jul. 23, 2009
Keith R. Fandrick, Sandy Hook, CT (US);
Joe Ju Gao, Southbury, CT (US);
Wenjie LI, Hopewell Junction, NY (US);
Zhi-hui LU, Newtown, CT (US);
Yongda Zhang, Richmond, VA (US);
Keith R. Fandrick, Sandy Hook, CT (US);
Joe Ju Gao, Southbury, CT (US);
Wenjie Li, Hopewell Junction, NY (US);
Zhi-Hui Lu, Newtown, CT (US);
Yongda Zhang, Richmond, VA (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).