The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Oct. 16, 2009
Philip Wilson Howard, London, GB;
Stephen John Gregson, London, GB;
Zhizhi Chen, London, GB;
Arnaud Charles Tiberghien, London, GB;
Luke Masterson, London, GB;
Philip Wilson Howard, London, GB;
Stephen John Gregson, London, GB;
ZhiZhi Chen, London, GB;
Arnaud Charles Tiberghien, London, GB;
Luke Masterson, London, GB;
Spirogen Developments SARL, St-Legier-La Chiesaz, CH;
Abstract
The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: Ris CHR, and Ris independently selected from H, R, COR, COR, CHO, COH, and halo; Rand Rare independently selected from H, R, OH, OR, SH, SR, NH, NHR, NRR', NO, MeSn and halo; Ris independently selected from H, R, OH, OR, SH, SR, NH, NHR, NRR′, NO, MeSn and halo; Ris independently selected from H, R, OH, OR, SH, SR, NH, NHR, NRR′, NO, MeSn and halo; R is independently selected from optionally substituted Calkyl, Cheterocyclyl and Caryl groups; or the compound is a dimer with each monomer being of formula (M), where the Rgroups or Rgroups of each monomer form together a dimer bridge having the formula —X—R″—X— linking the monomers; wherein R″ is a Calkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), and/or aromatic rings, e.g. benzene or pyridine; and each X is independently selected from O, S, or N(H); or any pair of adjacent groups from Rto Rtogether form a group —O—(CH)—O—, where p is 1 or 2, and salts and solvates thereof, and their use as intermediates for the preparation of other PBD compounds.