The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Nov. 05, 2009
Chao-chi Pan, Hsinchu, TW;
Jenn-yeh Fann, Hsinchu County, TW;
Chung-fan Chiou, Hsinchu County, TW;
Hung-chi Chien, Hsinchu, TW;
Hui-ling Chen, Hsinchu, TW;
Chao-Chi Pan, Hsinchu, TW;
Jenn-Yeh Fann, Hsinchu County, TW;
Chung-Fan Chiou, Hsinchu County, TW;
Hung-Chi Chien, Hsinchu, TW;
Hui-Ling Chen, Hsinchu, TW;
Industrial Technology Research Institute, Hsinchu, TW;
Abstract
Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.