The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Dec. 16, 2009
Miloud Rahmouni, Pierrefonds, CA;
Sonia Gervais, Laval, CA;
Vinayak Sant, Montreal, CA;
Damon Smith, Saint-Laurent, CA;
Frederic Duffayet, Montreal, CA;
Shams Rustom, Saint-Laurent, CA;
Ali El-jammal, Montreal, CA;
Jean-michel Ndong, Repentigny, CA;
Ali Bichara, Montreal, CA;
Miloud Rahmouni, Pierrefonds, CA;
Sonia Gervais, Laval, CA;
Vinayak Sant, Montreal, CA;
Damon Smith, Saint-Laurent, CA;
Frederic Duffayet, Montreal, CA;
Shams Rustom, Saint-Laurent, CA;
Ali El-Jammal, Montreal, CA;
Jean-Michel Ndong, Repentigny, CA;
Ali Bichara, Montreal, CA;
Paladin Labs Inc., Montreal (Quebec), CA;
Paladin Labs (Barbados) Inc., Hastings, Christ Church, BB;
Paladin Labs Europe Limited, Dublin, IE;
Abstract
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. The second layer, which can be adjacent the first layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles in the first layer. The composition further comprises a superabsorbent material (for example, polycarbophil) disposed within the first layer, the second layer, or both the first layer and the second layer. When intact, the pharmaceutically active agent is released from the second layer faster than the pharmaceutically active agent in the first layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition. Also disclosed is a method of using the misuse preventative, controlled release composition to deliver at least one pharmaceutically active agent to a mammal, for example, a human, in need thereof.