The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2013
Filed:
Nov. 01, 2004
Ralph Weissleder, Charlestown, MA (US);
Ching-hsuan Tung, Natick, MA (US);
Umar Mahmood, Boston, MA (US);
Lee Josephson, Arlington, MA (US);
Alexei Bogdanov, Arlington, MA (US);
Ralph Weissleder, Charlestown, MA (US);
Ching-Hsuan Tung, Natick, MA (US);
Umar Mahmood, Boston, MA (US);
Lee Josephson, Arlington, MA (US);
Alexei Bogdanov, Arlington, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.