The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
Oct. 23, 2009
Yongjun Mao, Shanghai, CN;
Jianfeng LI, Shanghai, CN;
Jin Zheng, Shanghai, CN;
Zheng Liu, Shanghai, CN;
Kai Xie, Shanghai, CN;
Haihong LI, Shanghai, CN;
Jing Shi, Shanghai, CN;
YE LI, Shanghai, CN;
Jingshan Shen, Shanghai, CN;
Yongjun Mao, Shanghai, CN;
Jianfeng Li, Shanghai, CN;
Jin Zheng, Shanghai, CN;
Zheng Liu, Shanghai, CN;
Kai Xie, Shanghai, CN;
Haihong Li, Shanghai, CN;
Jing Shi, Shanghai, CN;
Ye Li, Shanghai, CN;
Jingshan Shen, Shanghai, CN;
Topharman Shanghai Co., Ltd., Pudong, Shanghai, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhang Jiang, Pudong, CN;
Abstract
The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.