The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
May. 21, 2012
Wolfgang Ebel, Philadelphia, PA (US);
Luigi Grasso, Bryn Mawr, PA (US);
Nicholas C. Nicolaides, Garnett Valley, PA (US);
Philip M. Sass, Audobon, PA (US);
Eric Routhier, Glen Mills, PA (US);
Wolfgang Ebel, Philadelphia, PA (US);
Luigi Grasso, Bryn Mawr, PA (US);
Nicholas C. Nicolaides, Garnett Valley, PA (US);
Philip M. Sass, Audobon, PA (US);
Eric Routhier, Glen Mills, PA (US);
Morphotek, Inc., Exton, PA (US);
Abstract
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.