Substituted 2-(5-hydroxy-2-methyl-1h-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases

Abstract

The present invention relates to novel substituted 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acids, to novel antiviral active ingredients, pharmaceutical compositions, antiviral medicaments, methods for prophylaxis and treatment of viral diseases particularly caused by influenza viruses and infectious hepatisis C (HCV) viruses. Novel substituted 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acids, their esters of the general formula 1 and pharmaceutically acceptable salts and/or hydrates thereof have been disclosed wherein: Rrepresents amino group substituent selected from hydrogen, optionally substituted C-Calkyl, acyl or sulfonyl; Rand Rindependently of each other represent alkyl substituent selected from hydrogen, halogen, optionally substituted C-Calkyl, optionally substituted hydroxyl, optionally substituted amino group, optionally substituted aminomethyl, substituted mercapto group; Rrepresents hydrogen, optionally substituted lower C-Calkyl; Rrepresents cyclic system substituent selected from hydrogen, fluorine, trifluoromethyl, carboxy group, alkyloxycarbonyl, possibly substituted aryl, heterocyclyl, optionally substituted aminomethyl, cyano group; Rrepresents hydroxyl group substituent selected from hydrogen, optionally substituted C-Calkyl, acyl.