The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
May. 09, 2007
Applicants:
Laurence H. Hurley, Tucson, AZ (US);
Mary Guzman, Tucson, AZ (US);
Inventors:
Laurence H. Hurley, Tucson, AZ (US);
Mary Guzman, Tucson, AZ (US);
Assignee:
The Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/535 (2006.01);
U.S. Cl.
CPC ...
Abstract
Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective amount of a compound which triggers the release of nucleolin from the G-quadruplexes in rDNA. As specifically exemplified, the compound which increases nucleolin binding is a substituted quinobenzoxazine analog, for example CX-3543.