The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
Mar. 20, 2009
Dolores Fregona, S. Pietro Viminario, IT;
Luca Ronconi, Padua, IT;
Fernando Formaggio, Noventa Vicentina, IT;
Q. Ping Dou, Grosse Pointe, MI (US);
Donatella Aldinucci, Cordenons, IT;
Dolores Fregona, S. Pietro Viminario, IT;
Luca Ronconi, Padua, IT;
Fernando Formaggio, Noventa Vicentina, IT;
Q. Ping Dou, Grosse Pointe, MI (US);
Donatella Aldinucci, Cordenons, IT;
Universita' Degli Studi di Padova, Padua, IT;
Centro di Riferimento Oncologico, Aviano, IT;
Wayne State University Board of Govenors, Detroit, MI (US);
Abstract
The invention concerns Au(III) complexes of the type [AuX(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.