The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
Oct. 27, 2006
Kiyotaka Kuzushima, Nagoya, JP;
Yoshinori Ito, Nagoya, JP;
Ayako Okamura, Nagoya, JP;
Yoshiki Akatsuka, Nagoya, JP;
Yasuo Morishima, Nagoya, JP;
Kiyotaka Kuzushima, Nagoya, JP;
Yoshinori Ito, Nagoya, JP;
Ayako Okamura, Nagoya, JP;
Yoshiki Akatsuka, Nagoya, JP;
Yasuo Morishima, Nagoya, JP;
Medical and Biological Laboratories Co., Ltd., Nagoya-shi, Aichi, JP;
Abstract
The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr virus-specific cytotoxic T cells. The present inventors also demonstrated that the cytotoxic T cells recognized epitope peptides presented via HLA-A*0206, HLA-Cw*0303, or HLA-Cw*0304, inhibited the outgrowth of Epstein-Barr virus-infected B cells, and lysed Epstein-Barr virus-infected NK lymphomas and NK cells.