The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2013
Filed:
Aug. 22, 2007
Qui-lim Choo, El Cerrito, CA (US);
Jang Han, Lafayette, CA (US);
Michael Houghton, Danville, CA (US);
Taewoo Kwon, Oakland, CA (US);
Hyun Chul Song, Eunpyung-gu, SG;
Yifei Zhu, Fremont, CA (US);
Qui-Lim Choo, El Cerrito, CA (US);
Jang Han, Lafayette, CA (US);
Michael Houghton, Danville, CA (US);
Taewoo Kwon, Oakland, CA (US);
Hyun Chul Song, Eunpyung-gu, SG;
Yifei Zhu, Fremont, CA (US);
Novartis Vaccines and Diagnostics, Inc., Emeryville, CA (US);
Abstract
A tissue culture system for production of infectious hepatitis C virus is described. In particular, the invention provides recombinant monocistronic and bicistronic genomic constructs for production of virus, including constructs for production of wild-type HCV type 2a strain JFH1 and constructs for production of chimeric viruses comprising HCV proteins from strain JFH1 and a second HCV isolate. Constructs of the invention also include a reporter gene to facilitate measurement of RNA replication and viral infectivity in cultures. The cell culture system may also include various factors that improve viral replication or infectivity. In addition, a neutralization assay using HCV grown in cell culture is described.