The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8476408 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 02, 2013

Filed:

Jun. 11, 2009
Applicants:

Maria Brizzi, Turin, IT;

Giampiero Muccioli, Turin, IT;

Ezio Ghigo, Turin, IT;

Inventors:

Maria Brizzi, Turin, IT;

Giampiero Muccioli, Turin, IT;

Ezio Ghigo, Turin, IT;

Assignee:

Alize Pharma SAS, Ecully, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1.


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