The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2013

Filed:

Sep. 11, 2012
Applicants:

Ichiro Yoshida, Ibaraki, JP;

Tadashi Okabe, Ibaraki, JP;

Yasunobu Matsumoto, Ibaraki, JP;

Nobuhisa Watanabe, Ibaraki, JP;

Yoshiaki Ohashi, Ibaraki, JP;

Yuji Onizawa, Ibaraki, JP;

Hitoshi Harada, Ibaraki, JP;

Inventors:

Ichiro Yoshida, Ibaraki, JP;

Tadashi Okabe, Ibaraki, JP;

Yasunobu Matsumoto, Ibaraki, JP;

Nobuhisa Watanabe, Ibaraki, JP;

Yoshiaki Ohashi, Ibaraki, JP;

Yuji Onizawa, Ibaraki, JP;

Hitoshi Harada, Ibaraki, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound represented by formula (1) or a pharmaceutically acceptable salt thereof has an inhibitory effect in the fractalkine-CX3CR1 pathway: wherein R represents a Calkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, a Ccycloalkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, or a Ccycloalkenyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, X represents a Calkyl group, Y and Z are the same or different from each other and each represents a halogen atom or a Calkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group B, n represents 0 or 1, Substituent Group A consists of halogen atoms, and Substituent Group B consists of halogen atoms.


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