The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2013

Filed:

Oct. 18, 2012
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Kevin D. McCormick, Basking Ridge, NJ (US);

Li Dong, Lawrenceville, NJ (US);

Christopher W. Boyce, Flemington, NJ (US);

Manuel de Lera Ruiz, Branchburg, NJ (US);

Salem Fevrier, Cranford, NJ (US);

Jie Wu, Scotch Plains, NJ (US);

Junying Zheng, New Providence, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Jianhua Chao, San Diego, CA (US);

Walter S. Won, Alpine, NJ (US);

Ashwin U. Rao, Morganville, NJ (US);

Rongze Kuang, Green Brook, NJ (US);

Pauline C. Ting, New Providence, NJ (US);

Xianhai Huang, Warren, NJ (US);

Ning Shao, Clark, NJ (US);

Anandan Palani, Bridgewater, NJ (US);

Michael Y. Berlin, Flemington, NJ (US);

Robert G. Aslanian, Rockaway, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/501 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/4439 (2006.01); A61K 31/427 (2006.01); A61K 31/423 (2006.01); C07D 235/02 (2006.01); C07D 405/02 (2006.01); C07D 409/02 (2006.01); C07D 413/02 (2006.01); C07D 263/52 (2006.01);
U.S. Cl.
CPC ...
Abstract

In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.


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