The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Sep. 25, 2010
Guoliang Zhu, Zhejiang, CN;
Jian Zhang, Zhejiang, CN;
Lijun Yang, Zhejiang, CN;
Qingdan Yao, Zhejiang, CN;
Jie Ying, Zhejiang, CN;
Guoliang Zhu, Zhejiang, CN;
Jian Zhang, Zhejiang, CN;
Lijun Yang, Zhejiang, CN;
Qingdan Yao, Zhejiang, CN;
Jie Ying, Zhejiang, CN;
Abstract
The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following: