The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
May. 07, 2009
Rogelio P. Frutos, Sandy Hook, CT (US);
Thomas G. Tampone, Southbury, CT (US);
Jason Alan Mulder, New Milford, CT (US);
Dhileepkumar Krishnamurthy, Brookfield, CT (US);
Chris H. Senanayake, Brookfield, CT (US);
Rogelio P. Frutos, Sandy Hook, CT (US);
Thomas G. Tampone, Southbury, CT (US);
Jason Alan Mulder, New Milford, CT (US);
Dhileepkumar Krishnamurthy, Brookfield, CT (US);
Chris H. Senanayake, Brookfield, CT (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.