The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Nov. 25, 2009
Jian Hui Wu, Montreal, CA;
Gérald Batist, Montreal, CA;
Jinming Zhou, Beijing, CN;
Guoyan Geng, Montreal, CA;
Rongtuan Lin, Dollard-des-Ormeaux, CA;
Yi LI, Hubei, CN;
Jian Hui Wu, Montreal, CA;
Gérald Batist, Montreal, CA;
Jinming Zhou, Beijing, CN;
Guoyan Geng, Montreal, CA;
Rongtuan Lin, Dollard-des-Ormeaux, CA;
Yi Li, Hubei, CN;
TRT Pharma Inc., Montreal, CA;
Abstract
The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.