The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Aug. 28, 2009
Danila Branca, Rome, IT;
Federica Ferrigno, Rome, IT;
Jose Ignacio Martin Hernando, Rome, IT;
Philip Jones, Brookline, MA (US);
Olaf Kinzel, Rome, IT;
Savina Malancona, Rome, IT;
Ester Muraglia, Rome, IT;
Maria Cecilia Palumbi, Rome, IT;
Giovanna Pescatore, Rome, IT;
Rita Scarpelli, Rome, IT;
Danila Branca, Rome, IT;
Federica Ferrigno, Rome, IT;
Jose Ignacio Martin Hernando, Rome, IT;
Philip Jones, Brookline, MA (US);
Olaf Kinzel, Rome, IT;
Savina Malancona, Rome, IT;
Ester Muraglia, Rome, IT;
Maria Cecilia Palumbi, Rome, IT;
Giovanna Pescatore, Rome, IT;
Rita Scarpelli, Rome, IT;
Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.