The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Dec. 04, 2009
Phillip Frost, Miami Beach, FL (US);
Nadine Dejneka, Wynnewood, PA (US);
Ottrina S. Bond, Aventura, FL (US);
Naveed Shams, Danville, CA (US);
Phillip Frost, Miami Beach, FL (US);
Nadine Dejneka, Wynnewood, PA (US);
Ottrina S. Bond, Aventura, FL (US);
Naveed Shams, Danville, CA (US);
Opko Pharmaceuticals, LLC., Miami, FL (US);
Abstract
Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Such compositions and methods further involve siRNA capable of selectively targeting angiogenic VEGF isoforms while selectively sparing anti-angiogenic isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.