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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8470576 B1

PDFFull Text
Date of Patent:
Jun. 25, 2013

Filed:

Apr. 05, 2007

Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity

Applicants:

Jürgen Eck, Bensheim, DE;

Klaus Liebeton, Zwingenberg, DE;

Lutz Fischer, Stuttgart, DE;

Sabine Lutz-wahl, Kirchheim/Teck, DE;

Martina Hensel, Beitigheim-Bissingen, DE;

Christian Ewert, Weingarten, DE;

Marcus Wälz, Stuttgart, DE;

Inventors:

Jürgen Eck, Bensheim, DE;

Klaus Liebeton, Zwingenberg, DE;

Lutz Fischer, Stuttgart, DE;

Sabine Lutz-Wahl, Kirchheim/Teck, DE;

Martina Hensel, Beitigheim-Bissingen, DE;

Christian Ewert, Weingarten, DE;

Marcus Wälz, Stuttgart, DE;

Assignee:

B.R.A.I.N. AG, Zwingenberg, DE;

Attorney:

Pillsbury Winthrop Shaw Pittman LLP

Primary Examiner:

Yong Pak

Int. Cl.
CPC ...
C12N 9/78 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C12Q 1/68 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles.

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