The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2013
Filed:
Sep. 14, 2012
Applicants:
Richard Ross, Sheffield, GB;
Peter Artymiuk, Sheffield, GB;
Jon Sayers, Chesterfield, GB;
Inventors:
Assignee:
Asterion Limited, Sheffield, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/27 (2006.01); C07K 14/61 (2006.01); C07K 14/72 (2006.01); C12N 15/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract
We disclose growth hormone [GH] fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone deficiency that use said fusion proteins. The GH fusion proteins comprise human GH covalently linked to the extracellular domain of Growth Hormone Receptor [GHR] either as a direct in-frame translational fusion or via a flexible peptide linker. The GH/GHR fusion proteins have exceptional pharmacokinetics and are potent growth hormone receptor agonists. The GH/GHR fusion proteins form head to tail dimers.