The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2013
Filed:
Sep. 19, 2011
Applicants:
Stuart A. Lipton, La Jolla, CA (US);
Takumi Satoh, La Jolla, CA (US);
Inventors:
Stuart A. Lipton, La Jolla, CA (US);
Takumi Satoh, La Jolla, CA (US);
Assignee:
Sanford-Burnham Medical Research Institute, La Jolla, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 61/29 (2006.01);
U.S. Cl.
CPC ...
Abstract
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.