The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2013
Filed:
Feb. 28, 2003
Michele Orlando, The Hague, NL;
Jurgen Hemberger, Aschaffenburg, DE;
Klaus Sommermeyer, Rosbach, DE;
Wolfram Eichner, Butzbach, DE;
Sven Frie, Bramois, CH;
Katharina Lutterbeck, Friedberg, DE;
Cornelius Jungheinrich, Bad Homburg, DE;
Roland Scharpf, Ranstadt, DE;
Michele Orlando, The Hague, NL;
Jurgen Hemberger, Aschaffenburg, DE;
Klaus Sommermeyer, Rosbach, DE;
Wolfram Eichner, Butzbach, DE;
Sven Frie, Bramois, CH;
Katharina Lutterbeck, Friedberg, DE;
Cornelius Jungheinrich, Bad Homburg, DE;
Roland Scharpf, Ranstadt, DE;
Fresenius Kabi Deutschland GmbH, Bad Homburg v.d.H., DE;
Abstract
The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.