The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 18, 2013

Filed:

Feb. 27, 2009
Applicants:

Tom Yao Hsiang Wu, San Diego, CA (US);

Yongkai LI, San Diego, CA (US);

Alex Cortez, San Diego, CA (US);

Yefen Zou, San Diego, CA (US);

Pranab Mishra, San Diego, CA (US);

Xiaoyue Zhang, San Diego, CA (US);

David Skibinski, Siena, IT;

Manmohan Singh, Lexington, MA (US);

Nicholas Valiante, Cambridge, MA (US);

Inventors:

Tom Yao Hsiang Wu, San Diego, CA (US);

Yongkai Li, San Diego, CA (US);

Alex Cortez, San Diego, CA (US);

Yefen Zou, San Diego, CA (US);

Pranab Mishra, San Diego, CA (US);

Xiaoyue Zhang, San Diego, CA (US);

David Skibinski, Siena, IT;

Manmohan Singh, Lexington, MA (US);

Nicholas Valiante, Cambridge, MA (US);

Assignees:

IRM LLC, Hamilton, BM;

Novartis AG, Basel, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 471/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: Xis N; Xis N Or CR; Xis —CR═CR.


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