The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2013
Filed:
Dec. 30, 2010
Klarisa Rikova, Reading, MA (US);
Roberto Polakiewicz, Lexington, MA (US);
Ailan Guo, Lexington, MA (US);
Katherine Eleanor Crosby, Middleton, MA (US);
Qingfu Zeng, Hamilton, MA (US);
Kimberly a Lee, Seattle, WA (US);
Klarisa Rikova, Reading, MA (US);
Roberto Polakiewicz, Lexington, MA (US);
Ailan Guo, Lexington, MA (US);
Katherine Eleanor Crosby, Middleton, MA (US);
Qingfu Zeng, Hamilton, MA (US);
Kimberly A Lee, Seattle, WA (US);
Cell Signaling Technology, Inc., Danvers, MA (US);
Abstract
The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.