The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2013
Filed:
Oct. 29, 2007
Ariel Fernandez, Houston, TX (US);
William Bornmann, Missouri City, TX (US);
Gabriel Lopez-berestein, Bellaire, TX (US);
Angela Sanguino, Pittsburgh, PA (US);
Zheng-hong Peng, Missouri City, TX (US);
Anil K. Sood, Pearland, TX (US);
Ariel Fernandez, Houston, TX (US);
William Bornmann, Missouri City, TX (US);
Gabriel Lopez-Berestein, Bellaire, TX (US);
Angela Sanguino, Pittsburgh, PA (US);
Zheng-Hong Peng, Missouri City, TX (US);
Anil K. Sood, Pearland, TX (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.