The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2013
Filed:
Nov. 29, 2011
Chen-chao Wang, West Windsor, NJ (US);
Jaedeok Yoo, Princeton, NJ (US);
Esteban Bornancini, North Wales, PA (US);
Willie J Roach, Plainsboro, NJ (US);
Monica Tejwani, Monmouth Junction, NJ (US);
Chen-Chao Wang, West Windsor, NJ (US);
Jaedeok Yoo, Princeton, NJ (US);
Esteban Bornancini, North Wales, PA (US);
Willie J Roach, Plainsboro, NJ (US);
Monica Tejwani, Monmouth Junction, NJ (US);
The Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.