The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
May. 27, 2010
Alex Herman Copmans, Lille, BE;
Jérôme Albert Joseph Hoet, Braine-l'Alleud, BE;
Albert Louis Anna Willemsens, Beerse, BE;
Wouter Louis J Couck, Sint-Amandsberg, BE;
Joannes Petrus Van Dun, Lille, BE;
Alex Herman Copmans, Lille, BE;
Jérôme Albert Joseph Hoet, Braine-l'Alleud, BE;
Albert Louis Anna Willemsens, Beerse, BE;
Wouter Louis J Couck, Sint-Amandsberg, BE;
Joannes Petrus Van Dun, Lille, BE;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.