The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2013
Filed:
Sep. 15, 2008
Mildred Acevedo-duncan, Plant City, FL (US);
Shraddha R. Desai, Tampa, FL (US);
Hla Yee Win, Tampa, FL (US);
David A. Ostrov, Gainesville, FL (US);
Prajit P. Pillai, Tampa, FL (US);
Diondra D. Hill, Tampa, FL (US);
Mildred Acevedo-Duncan, Plant City, FL (US);
Shraddha R. Desai, Tampa, FL (US);
Hla Yee Win, Tampa, FL (US);
David A. Ostrov, Gainesville, FL (US);
Prajit P. Pillai, Tampa, FL (US);
Diondra D. Hill, Tampa, FL (US);
The University of South Florida, Tampa, FL (US);
The United States of America Department of Veterans Affairs, Washington, DC (US);
The University of Florida Research Foundation, Inc., Gainesville, FL (US);
Abstract
PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1α,2β,3β,4α)], (ICA-1), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to selectively inhibit the proliferation of cells that overexpress PKCiota.